Important Facts About Humulin® (HUE-mu-lin) R U-500. It is also known as insulin human injection (500 units/mL).
Humulin R U-500 is a prescription insulin used in adults and children who need more than 200 units of insulin a day to control high blood sugar for their diabetes mellitus. It is more concentrated than standard insulin. It has 5 times as much insulin in each mL as standard insulin.
It is not known if Humulin R U-500 is safe and effective when used with other insulins, when used in an insulin pump, or in children. There were no studies done in children, so your doctor will give you special instructions for use in children.
Humulin R U-500 may cause serious side effects, including:
Do not share your Humulin R U-500 KwikPen® or U-500 syringe with anyone. Even if you have changed the needle, you or the other person can get a serious infection.
When using the Humulin R U-500 KwikPen: The Humulin R U-500 KwikPen is made to dial and deliver the correct dose of Humulin R U-500 insulin. Do not remove Humulin R U-500 from the KwikPen to inject with any syringe. This could cause severe overdose and may lead to death.
When using the Humulin R U-500 vial: There is a special syringe to measure Humulin R U-500 called the "U-500 insulin syringe." Only use the U-500 insulin syringe to inject Humulin R U-500. If you do not use the right syringe, you may take the wrong dose of Humulin R U-500. This could cause severe overdose and may lead to death.
Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe.
Do not use Humulin R U-500 in an insulin pump or inject it into your vein or muscle.
Do not take this medicine if you have low blood sugar.
Do not change the insulin you use without talking to your doctor. Changing insulin may lead to low or high blood sugar.
Do not drive or use heavy machinery until you know how Humulin R U-500 affects you. Do not drink alcohol while using Humulin R U-500.
The most common side effects of Humulin R U-500 include:
These are not all the possible side effects of Humulin R U-500.
Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.
Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor about:
For more information, call 1-800-545-5979 or go to humulin.com.
This summary provides basic information about Humulin R U-500 but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Humulin R U-500 and how to take it. Your doctor is the best person to help you decide if Humulin R U-500 is right for you.
Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.
HM CON BS 15NOV2019