Get a hold of the chance for fewer daily injections.^*

Study conducted with U-100 insulin syringes and Humulin R U-500 vials.

Proven to lower A1C with the potential for fewer daily injections.^*

In a clinical study, U-500 was shown to lower A1C by an average of 1.1% points in people who were not well controlled on more than 200 units of standard U-100 insulin a day.^†

^*Compared to U-100 insulin. Most patients will require 2 or 3 daily injections of U-500.¹

^†The purpose of the study was to compare the efficacy and safety of 2 dosing treatments (2 or 3 injections per day) of U-500 in adults with type 2 diabetes who were uncontrolled with high doses of standard U-100 insulin. The results between the 2 treatments were similar.

1. Hood RC, Arakaki RF, Wysham C, et al. Two treatment approaches for human regular U-500 insulin in patients with type 2 diabetes not achieving adequate glycemic control on high-dose U-100 insulin therapy with or without oral agents: a randomized, titration-to-target clinical trial. Endocr Pract. 2015;21(7):782-793. Erratum, 2016;22(7):905

Humulin R U-500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day.

Select Important Safety Information for Humulin R U-500
Humulin R U-500 is highly concentrated and contains 5 times as much insulin in 1 mL as standard U-100 (100 units/mL) insulin.
Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500.

Need help paying for your Humulin R U-500 prescription?

Lilly is committed to helping people with diabetes access affordable medicines.

Woman in blue shirt standing confidently with hand on hip

Actor portrayal. Not an actual patient.

Download your $35/month Insulin Savings Card

I have commercial insurance

I pay cash

Through the Lilly Insulin Value Program, all Lilly insulins are available for $35 a month whether you have commercial insurance or no insurance.^*

These savings cover all Lilly insulins.

^*Terms and conditions apply. At retail pharmacies. Government restrictions exclude people enrolled in federal government insurance programs from Lilly's $35 solutions. But federal law provides that Medicare Part D beneficiaries also pay no more than $35 per month for insulin.

Learn more about the Lilly Insulin Affordability Program

Terms, Conditions and Limitations apply to the Insulin Value Savings Card. Click on the following sections for details.

By using the Lilly Insulin Value Cash Savings Card Program (“Card”), you attest that you meet the eligibility criteria, and you agree to comply with the terms and conditions described below:

Card Eligibility:

You have been prescribed one of the following Lilly Insulin Value products (“Covered Insulin”) consistent with FDA approved product labeling: BASAGLAR^® KwikPen^® (insulin glargine) injection (100 units/mL), BASAGLAR ^® Tempo Pen^®, Humalog^® U-100 cartridge (insulin lispro) injection (100 units per mL), Humalog^® U-100 KwikPen^®, Humalog^® U-100 vial (10 mL), Humalog^® Junior KwikPen^®, Humalog^® U-200 KwikPen^®, Humalog^® Mix50/50^™ KwikPen^® (insulin lispro protamine and insulin lispro) injectable suspension (100 units per mL), Humalog^® Mix50/50^™ vial (10 mL), Humalog^® Mix75/25^™ KwikPen^®(insulin lispro protamine and insulin lispro) injectable suspension (100 units per mL), Humalog^® Mix75/25^™ vial (10 mL), Humalog^® Tempo Pen^®, Humulin^® N KwikPen^®(insulin isophane human) injectable suspension (100 units per mL) , Humulin^® N vial (10 mL), Humulin^® 70/30 KwikPen^® (insulin isophane human and insulin human) injectable suspension (100 units per mL) , Humulin^® 70/30 vial (10 mL), Humulin^® R (insulin human) injection (10 mL), Humulin^® R U-500 KwikPen^® (insulin human) injection (500 units/mL), Humulin R U-500 vial, Insulin Lispro KwikPen^® injection (100 units per mL), Insulin Lispro injection vial (10mL), Insulin Lispro Junior KwikPen^® injection, Insulin Lispro Protamine and Insulin Lispro Mix75/25^™ KwikPen^® Injectable Suspension, Lyumjev^® KwikPen^® (insulin lispro-aabc) injection (100 units/mL), Lyumjev^® U-200 KwikPen^®, Lyumjev^® U-100 vial (10 mL), Lyumjev^® Tempo Pen^®, and REZVOGLAR™ KwikPen (insulin glargine-aglr) injection (100 units/mL).
You are not enrolled in any state, federal, or government funded healthcare program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medicare Advantage, Medigap, DoD, VA, TRICARE^®/CHAMPUS, or any state prescription drug assistance program.
You are a resident of the United States or a United States Territory (Puerto Rico, Guam, U.S. Virgin Islands, Northern Mariana Islands, American Samoa)
You are 18 years of age or older

Card Terms and Conditions
You must have a prescription consistent with FDA-approved product labeling to pay as little as $35 for a 1-month prescription fill of your Covered Insulin. Month is defined as 30-days. Card savings are subject to a maximum monthly savings of wholesale acquisition cost plus usual and customary pharmacy charges per prescription fill, up to a maximum of 14 prescription fills per calendar year for each Covered Insulin. Subject to Lilly USA, LLC’s (“Lilly”) right to terminate, rescind, revoke, or amend Card eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, Card expires and savings end on 12/31/2024.

Additional Program Terms and Conditions
If you have an insurance plan that is participating in an alternate funding program (“AFP”) (examples include, but are not limited to, ImpaxRX, Payer Matrix, SHARx, Script Sourcing, and Paydhealth) that requires you to apply to the Lilly Insulin Value Cash Savings Card Program or otherwise pursue specialty drug prescription coverage through an alternate funding vendor as a condition of, requirement for, or prerequisite to coverage of your Covered Insulin, you are not eligible for and are prohibited from using the Lilly Insulin Value Cash Savings Card Program. AFPs include programs where coverage, reimbursement, or patient out of pocket costs for a product in some way vary based on the availability of a manufacturer co-pay program. AFPs may modify, delay, deny, restrict, or withhold insurance benefits or coverage from patients, or exclude Lilly products from coverage contingent upon a member's use of Lilly Insulin Value Cash Savings Card Program. You agree to inform Lilly Insulin Value Cash Savings Card Program if you are or become a member of such an alternative funding program. You are responsible for any applicable taxes, fees, and any amount that exceeds the monthly or annual maximum Card savings. Monthly and annual maximum savings are set at Lilly's sole and absolute discretion and may be changed with or without notice at any time for any reason. At its sole discretion and with or without notice, Lilly may reduce, eliminate, or otherwise modify the Card savings for any reason including but not limited to if your commercial drug insurance plan imposes additional requirements which limits or prevents you from receiving coverage for your Covered Insulin, only allows partial coverage for your Covered Insulin, removes coverage for your Covered Insulin and requires you to utilize the Card, does not provide a material level of financial assistance for the cost of your Covered Insulin, or does not apply Card payments to satisfy your co-payment, deductible, or coinsurance for your Covered Insulin. Card savings are not valid for: Massachusetts residents if an AB-rated generic equivalent is available; California residents if an FDA-approved therapeutic equivalent is available. You must meet the Card eligibility criteria, terms and conditions every time you use the Card. Card activation is required. No party may seek reimbursement from your health insurance, any third party, or any health savings, flexible spending, or other healthcare reimbursement accounts, for any amount of the savings received through the Card. Card savings cannot be combined or utilized with any other program, discount, discount card, cash discount card, coupon, incentive, or similar offer involving your Covered Insulin. You agree that this Card savings is intended solely for the benefit of you, the patient, and that the Card benefits are nontransferable. It is prohibited for any person to sell, purchase, or trade; or to offer to sell, purchase, or trade, or to counterfeit the Card. The Card is not insurance. Lilly has the sole right to interpret and apply Card eligibility criteria, and terms and conditions. Card eligibility, and terms and conditions may be terminated, rescinded, revoked, or amended by Lilly at any time without notice and for any reason. Eligibility criteria, and terms and conditions for the Lilly Insulin Value Cash Savings Card Program may change from time to time; the most current version can be found at https://www.insulinaffordability.com. You may be required to obtain a new Card, including if any Card terms and conditions have been terminated, rescinded, revoked, or amended by Lilly. Card void where prohibited by law. Subject to Lilly’s right to terminate, rescind, revoke or amend Card eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, the Card expires and savings end on 12/31/2024.

By using the Lilly Insulin Value Savings Card Program (“Card”), you attest that you meet the eligibility criteria, and you agree to comply with the terms and conditions described below:

Card Eligibility:

You have been prescribed one of the following Lilly Insulin Value products (“Covered Insulin”) consistent with FDA approved product labeling: BASAGLAR^® KwikPen^® (insulin glargine) injection (100 units/mL), BASAGLAR ^® Tempo Pen^®, Humalog^® U-100 cartridge (insulin lispro) injection (100 units per mL), Humalog^® U-100 KwikPen^®, Humalog^® U-100 vial (10 mL), Humalog^® Junior KwikPen^®, Humalog^® U-200 KwikPen^®, Humalog^® Mix50/50^™ KwikPen^® (insulin lispro protamine and insulin lispro) injectable suspension (100 units per mL), Humalog^® Mix50/50^™ vial (10 mL), Humalog^® Mix75/25^™ KwikPen^®(insulin lispro protamine and insulin lispro) injectable suspension (100 units per mL), Humalog^® Mix75/25^™ vial (10 mL), Humalog^® Tempo Pen^®, Humulin^® N KwikPen^®(insulin isophane human) injectable suspension (100 units per mL) , Humulin^® N vial (10 mL), Humulin^® 70/30 KwikPen^® (insulin isophane human and insulin human) injectable suspension (100 units per mL) , Humulin^® 70/30 vial (10 mL), Humulin^® R (insulin human) injection (10 mL), Humulin^® R U-500 KwikPen^® (insulin human) injection (500 units/mL), Humulin R U-500 vial, Insulin Lispro KwikPen^® injection (100 units per mL), Insulin Lispro injection vial (10mL), Insulin Lispro Junior KwikPen^® injection, Insulin Lispro Protamine and Insulin Lispro Mix75/25^™ KwikPen^® Injectable Suspension, Lyumjev^® KwikPen^® (insulin lispro-aabc) injection (100 units/mL), Lyumjev^® U-200 KwikPen^®, Lyumjev^® U-100 vial (10 mL), Lyumjev^® Tempo Pen^®, and REZVOGLAR^™ KwikPen (insulin glargine-aglr) injection (100 units/mL).
You are enrolled in a commercial drug insurance plan
You are not enrolled in any state, federal, or government funded healthcare program, including, without limitation, Medicaid, Medicare, Medicare Part D, Medicare Advantage, Medigap, DoD, VA, TRICARE^®/CHAMPUS, or any state prescription drug assistance program.
You are a resident of the United States or a United States Territory (Puerto Rico, Guam, U.S. Virgin Islands, Northern Mariana Islands, American Samoa)
You are 18 years of age or older

Card Terms and Conditions

For patients with commercial drug insurance coverage for your Covered Insulin: You must have commercial drug insurance that covers your Covered Insulin and a prescription consistent with FDA-approved product labeling to pay as little as $35 for a 1-month prescription fill of your Covered Insulin. Month is defined as 30-days. Card savings are subject to a maximum monthly savings of up to $3,000 per prescription fill of each Covered Insulin and separate maximum annual savings of up to $16,000 per calendar year for each Covered Insulin. Card may be used for a maximum of up to 16 prescription fills per calendar year for each Covered Insulin. Subject to Lilly USA, LLC’s (“Lilly”) right to terminate, rescind, revoke, or amend Card eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, Card expires and savings end on 12/31/2024.

For patients with commercial drug insurance who do not have coverage for your Covered Insulin: You must have commercial drug insurance that does not cover your Covered Insulin and a prescription consistent with FDA-approved product labeling to pay as little as $35 for a 1-month prescription fill of your Covered Insulin. Month is defined as 30-days. Card savings are subject to a maximum monthly savings of wholesale acquisition cost plus usual and customary pharmacy charges per prescription fill, up to a maximum of 14 prescription fills per calendar year for each Covered Insulin. Subject to Lilly’s right to terminate, rescind, revoke, or amend Card eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, Card expires and savings end on 12/31/2024.

Additional Program Terms and Conditions
If you have an insurance plan that is participating in an alternate funding program (“AFP”) (examples include, but are not limited to, ImpaxRX, Payer Matrix, SHARx, Script Sourcing, and Paydhealth) that requires you to apply to the Lilly Insulin Value Savings Card Program or otherwise pursue specialty drug prescription coverage through an alternate funding vendor as a condition of, requirement for, or prerequisite to coverage of your Covered Insulin, you are not eligible for and are prohibited from using the Lilly Insulin Value Savings Card Program. AFPs include programs where coverage, reimbursement, or patient out of pocket costs for a product in some way vary based on the availability of a manufacturer co-pay program. AFPs may modify, delay, deny, restrict, or withhold insurance benefits or coverage from patients, or exclude Lilly products from coverage contingent upon a member’s use of Lilly Insulin Value Savings Card Program. You agree to inform Lilly Insulin Value Savings Card Program if you are or become a member of such an alternative funding program. You are responsible for any applicable taxes, fees, and any amount that exceeds the monthly or annual maximum Card savings. Monthly and annual maximum savings are set at Lilly’s sole and absolute discretion and may be changed with or without notice at any time for any reason. At its sole discretion and with or without notice, Lilly may reduce, eliminate, or otherwise modify the Card savings for any reason, including but not limited to if your commercial drug insurance plan imposes additional requirements which limits or prevents you from receiving coverage for your Covered Insulin, only allows partial coverage for your Covered Insulin, removes coverage for your Covered Insulin and requires you to utilize the Card, does not provide a material level of financial assistance for the cost of your Covered Insulin, or does not apply Card payments to satisfy your co-payment, deductible, or coinsurance for your Covered Insulin. Card savings are not valid for: Massachusetts residents if an AB-rated generic equivalent is available; California residents if an FDA-approved therapeutic equivalent is available. You must meet the Card eligibility criteria, terms and conditions every time you use the Card. Card activation is required. No party may seek reimbursement from your health insurance, any third party, or any health savings, flexible spending, or other healthcare reimbursement accounts, for any amount of the savings received through the Card. By utilizing the Card, you agree that if you are required to do so under the terms of your insurance coverage for this prescription or are otherwise required to do so by law, you will notify your Insurance Carrier of your redemption of the Card. Card savings cannot be combined or utilized with any other program, discount, discount card, cash discount card, coupon, incentive, or similar offer involving your Covered Insulin. You agree that this Card savings is intended solely for the benefit of you, the patient, and that the Card benefits are nontransferable. It is prohibited for any person to sell, purchase, or trade; or to offer to sell, purchase, or trade, or to counterfeit the Card. The Card is not insurance. Lilly has the sole right to interpret and apply Card eligibility criteria, and terms and conditions. Card eligibility, and terms and conditions may be terminated, rescinded, revoked, or amended by Lilly at any time without notice and for any reason. Eligibility criteria, and terms and conditions for the Lilly Insulin Value Savings Card Program may change from time to time; the most current version can be found at https://www.insulinaffordability.com. You may be required to obtain a new Card, including if any Card terms and conditions have been terminated, rescinded, revoked, or amended by Lilly. Card void where prohibited by law. Subject to Lilly’s right to terminate, rescind, revoke or amend Card eligibility criteria and/or Card terms and conditions which may occur at Lilly’s sole discretion, without notice, and for any reason, the Card expires and savings end on 12/31/2024.

Anyone who uses Lilly insulin and needs help with diabetes care can call the Lilly Diabetes Solution Center. A live representative will have a confidential conversation and present solutions that are based on each person’s circumstances. The helpline is available Monday through Friday.

Call 1-833-808-1234

Solutions vary by product and are subject to change and eligibility.

LillyDirect: Connect to Care

Get speed, convenience, and access to focused care with independent telehealth or in-person providers through LillyDirect.

Get started

SAFETY SUMMARY

Warnings:

Humulin R U-500 may cause serious side effects, including:

Severe low blood sugar, which can lead to seizures, unconsciousness, and death.
Severe allergic reactions. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
Swelling of your hands and feet. Tell your doctor if you are short of breath, have swelling in your ankles, or have gained weight suddenly.
Heart failure when taking a medication from a class of drugs called thiazolidinediones (TZDs) with Humulin R U-500. This may occur in some people even if they have not had heart problems before.
Low potassium in your blood (hypokalemia). This can lead to severe breathing problems, irregular heartbeat, and death.

Do not share your Humulin R U-500 KwikPen^® or U-500 syringe with anyone. Even if you have changed the needle, you or the other person can get a serious infection.

When using the Humulin R U-500 KwikPen: The Humulin R U-500 KwikPen is made to dial and deliver the correct dose of Humulin R U-500 insulin. Do not remove Humulin R U-500 from the KwikPen to inject with any syringe. This could cause severe overdose and may lead to death.

When using the Humulin R U-500 vial: There is a special syringe to measure Humulin R U-500 called the “U-500 insulin syringe.” Only use the U-500 insulin syringe to inject Humulin R U-500. If you do not use the right syringe, you may take the wrong dose of Humulin R U-500. This could cause severe overdose and may lead to death.

Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe.

Do not use Humulin R U-500 in an insulin pump or inject it into your vein.

Do not take this medicine if you have low blood sugar.

Do not change the insulin you use without talking to your doctor. Changing insulin may lead to low or high blood sugar.

Do not drive or use heavy machinery until you know how Humulin R U-500 affects you. Do not drink alcohol while using Humulin R U-500.

Common side effects

The most common side effects of Humulin R U-500 include:

Low blood sugar (hypoglycemia). Talk to your doctor about low blood sugar symptoms and treatment. Symptoms may be different for each person.
Allergic reactions, such as redness and swelling at the site where you inject.
Skin thickening or pits at the injection site (lipodystrophy).
Itching and rash.

These are not all the possible side effects of Humulin R U-500.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch .

Before using

Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor about:

Any allergies you have. Your doctor can check if the medicine has ingredients that may cause a reaction.
Any medical conditions, including problems with your liver, kidney, or heart.
All the medicines you take, especially a class of drugs called thiazolidinediones, or TZDs. Be sure to include the over-the-counter medicines, vitamins, and herbal supplements you take.

How to take

Read the instructions that come with your Humulin R U-500 carefully. Take it exactly the way your doctor tells you.
Know how much Humulin R U-500 you are supposed to take. Do not change your dose unless your doctor tells you to.
Check the label of your insulin each time you use it. This will help you make sure you are using the right one.
Test your blood sugar before you take Humulin R U-500. Do not take it if your blood sugar is too low.
Do not mix Humulin R U-500 with any other insulin.
Always use a new needle when injecting Humulin R U-500. This will help you avoid infection.
Inject Humulin R U-500 under your skin. Change (rotate) where you inject your insulin with each dose. Do not inject your insulin into the exact same spot. Avoid injecting your insulin into areas where the skin has pits or lumps, or is thickened, tender, bruised, scaly, hard, scarred, or damaged. This will help reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin.

Learn more

Humulin R U-500 is a prescription medicine. For more information, call 1-800-545-5979.

This summary provides basic information about Humulin R U-500 but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Humulin R U-500 and how to take it. Your doctor is the best person to help you decide if Humulin R U-500 is right for you.

HM CON BS 02FEB2023

Humulin^® and KwikPen^® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

INDICATION

Humulin^® (HUE-mu-lin) R U-500 (500 units/mL) is for adults and children who need more than 200 units of insulin in a day to control high blood sugar for their diabetes mellitus. It is more concentrated than Humulin R U-100. It has 5 times as much insulin in each mL as Humulin R U-100 (100 units/mL).

It is not known if Humulin R U-500 is safe and effective when used with other insulins or when used in an insulin pump.

Get a hold of the chance for fewer daily injections.*