Other Available Humulin Insulins

Introduced by Eli Lilly and Company in 1982, Humulin U-100 insulins are affordable choices that celebrate over 30 years of helping people manage type 1 and type 2 diabetes.

For the treatment of high blood sugar (glucose) levels, 3 types of Humulin U-100 insulin can help manage diabetes. Each insulin type varies in onset, peak time and duration. Keep in mind that insulin should only be used under a healthcare provider’s advice and care.

Humulin R U-100

Provides a short-acting insulin peak to cover blood sugar increases from meals eaten within 30 minutes

Humulin N

Provides an intermediate-acting insulin peak to cover blood sugar increases between meals and during the night

Humulin 70/30

Short-and intermediate-acting insulin peaks combined to cover insulin needs after meals, throughout the day, and at night

What is Humulin® R U-100?

Short-acting insulin to cover blood sugar increases from meals eaten within 30 minutes

Humulin R U-100 is a short-acting insulin, which means it can cover insulin needs for meals eaten within 30 minutes.

There are 2 types of Humulin R insulin: Humulin R U-100 and a more concentrated insulin, Humulin R U-500. U-100 insulins, including Humulin R, contain 100 units per mL. It’s important to make sure you have the correct one.

Humulin R U-100 is for injection under the skin. It should not be injected into the muscle. Doses of insulin are measured in units. With Humulin R U-100, it is important to use a syringe that is marked for U-100 insulins.

Do not use Humulin R U-100:

  • If it appears cloudy, thickened, or slightly colored, or
  • If solid particles are visible

If you notice your insulin requirements changing, talk to your doctor.

Be sure to read the Patient Information that comes with your Humulin R U-100 insulin.

Also be sure to read the Instructions for Use for your Humulin R U-100 vial.

To learn more about Humulin R U-100, call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

Pens and needles are for single-patient use only and should not be shared, even in healthcare facilities, as infection or disease can be spread from one person to another.

Do not withdraw insulin from the pen using a syringe.

Indication

Humulin R U-100 is indicated as an adjunct to diet and exercise to improve glycemic control in adults and children with type 1 and type 2 diabetes mellitus.

For more safety information, please click to access Humulin R U-100 Patient Information and Humulin R U-100 Full Prescribing Information.

What is Humulin® N?

Intermediate-acting insulin to cover blood sugar increases between meals and during the night

Humulin N is an intermediate acting insulin that is slower to act and lasts longer than regular human insulin. Humulin N is available in the prefilled Humulin® N KwikPen® or in a Humulin N U-100 vial.

Humulin N is injected under the skin. It should not be injected into muscle or veins. Doses of insulin are measured in units. U-100 insulins, including Humulin N, contain 100 units/mL. With the Humulin N U-100 vial, it is important to use a syringe that is marked for U-100 insulin preparations.

Do not use Humulin N:

  • If the insulin substance (the white material) remains at the bottom of the bottle after mixing, or
  • If there are clumps in the insulin after mixing

If you notice your insulin requirements changing, talk to your doctor.

Be sure to read the Patient Information that comes with your Humulin N insulin.

Also be sure to read the Instructions for Use for your Humulin N vial or KwikPen

To learn more about Humulin N KwikPen, call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

Pens and needles are for single-patient use only and should not be shared, even in healthcare facilities, as infection or disease can be spread from one person to another.

Do not withdraw insulin from the pen using a syringe.

Indication

Humulin N is used to treat people with diabetes for the control of high blood sugar.

Important Considerations for Use for Humulin R U-100, Humulin N, and Humulin 70/30:

  • Low blood sugar (hypoglycemia) is the most common side effect of insulin, including Lilly Humulin insulins. Signs of severe hypoglycemia can include: disorientation, unconsciousness, seizures, or death.
  • Humulin KwikPens must never be shared, even if the needle is changed. If you use Humulin vials, you must never share needles or syringes with another person. Sharing poses a risk that you may give someone a serious infection or get a serious infection from them.
  • Any change of insulin should be made cautiously and only under medical supervision.
  • Changes in strength, manufacturer, type (eg, regular, NPH, analog), species, or method of manufacture may result in the need for a change in dosage.
  • Some patients taking Humulin may require a change in dosage from that used with other insulins. If an adjustment is needed, it may occur with the first dose or during the first several weeks or months.
  • High blood sugar (hyperglycemia) may develop if the body has too little insulin. In people with type 1 or insulin-dependent diabetes, prolonged hyperglycemia can result in diabetic ketoacidosis (DKA). DKA is a life-threatening emergency.
  • Always check the carton and bottle label for the name and letter designation of the insulin received from the pharmacy to make sure it’s the correct insulin.
  • Do not use any other insulin except on your healthcare provider's advice and direction.
  • Do not use Humulin after the expiration date stamped on the label or if it has been frozen.
  • Do not share needles or syringes, because you may give or get an infection.
  • Before using Lilly Humulin insulin, tell your healthcare providers about all of your medical conditions, including liver, kidney, or heart problems, if you are pregnant or breast-feeding, and about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
  • Serious side effects can include heart failure when taking certain pills called thiazolidinediones or “TZDs” with Lilly Humulin insulin. Tell your healthcare provider if you have any new or worse symptoms of heart failure, such as shortness of breath, swelling of your ankles or feet, or sudden weight gain.

For more safety information, please click to access Humulin N Patient Information and Humulin N Full Prescribing Information.

Please see the Instructions for Use included with your pen.

What is Humulin® 70/30?

Short-and intermediate-acting insulins combined to cover insulin needs after meals, throughout the day, and at night

Humulin 70/30 is an insulin that combines the short action of regular human insulin (Humulin R U-100) and the intermediate action of HumulinN. Humulin 70/30 is available in the prefilled Humulin® 70/30 KwikPen® or in a Humulin 70/30 U-100 vial.

Humulin 70/30 is injected under the skin. It should not be injected into a vein or muscle. Doses of insulin are measured in units. U-100 insulins, including Humulin 70/30, contain 100 units/mL. With the Humulin 70/30 vial, it is important to use a syringe that is marked for U-100 insulins.

Do not use Humulin 70/30:

  • If the insulin substance (the white material) remains at the bottom of the bottle after mixing, or
  • If solid particles

If you notice your insulin requirements changing, talk to your doctor.

Be sure to read the Patient Information that comes with your Humulin 70/30 insulin.

Also be sure to read the Instructions for Use for your Humulin 70/30 vial or KwikPen

To learn more about Humulin 70/30 KwikPen, call The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

Pens and needles are for single-patient use only and should not be shared, even in healthcare facilities, as infection or disease can be spread from one person to another.

Do not withdraw insulin from the pen using a syringe.

Indication

Humulin 70/30 is used to treat people with diabetes for the control of high blood sugar.

Important Considerations for Use for Humulin R U-100, Humulin N, and Humulin 70/30:

  • Low blood sugar (hypoglycemia) is the most common side effect of insulin, including Lilly Humulin insulins. Signs of severe hypoglycemia can include: disorientation, unconsciousness, seizures, or death.
  • Humulin KwikPens must never be shared, even if the needle is changed. If you use Humulin vials, you must never share needles or syringes with another person. Sharing poses a risk that you may give someone a serious infection or get a serious infection from them.
  • Any change of insulin should be made cautiously and only under medical supervision.
  • Changes in strength, manufacturer, type (eg, regular, NPH, analog), species, or method of manufacture may result in the need for a change in dosage.
  • Some patients taking Humulin may require a change in dosage from that used with other insulins. If an adjustment is needed, it may occur with the first dose or during the first several weeks or months.
  • High blood sugar (hyperglycemia) may develop if the body has too little insulin. In people with type 1 or insulin-dependent diabetes, prolonged hyperglycemia can result in diabetic ketoacidosis (DKA). DKA is a life-threatening emergency.
  • Always check the carton and bottle label for the name and letter designation of the insulin received from the pharmacy to make sure it’s the correct insulin.
  • Do not use any other insulin except on your healthcare provider's advice and direction.
  • Do not use Humulin after the expiration date stamped on the label or if it has been frozen.
  • Do not share needles or syringes, because you may give or get an infection.
  • Before using Lilly Humulin insulin, tell your healthcare providers about all of your medical conditions, including liver, kidney, or heart problems, if you are pregnant or breast-feeding, and about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
  • Serious side effects can include heart failure when taking certain pills called thiazolidinediones or “TZDs” with Lilly Humulin insulin. Tell your healthcare provider if you have any new or worse symptoms of heart failure, such as shortness of breath, swelling of your ankles or feet, or sudden weight gain.

For more safety information, please click to access: Humulin R U-100 Patient Information, Humulin R U-100 Full Prescribing Information, Humulin N Patient Information, Humulin N Full Prescribing Information, Humulin 70/30 Patient Information, and Humulin 70/30 Full Prescribing Information. Please see Instructions for Use included with your Humulin N KwikPen or Humulin 70/30 KwikPen.

PURPOSE and SAFETY SUMMARY

Important Facts About Humulin® (HUE-mu-lin) R U-500. It is also known as insulin human injection (500 units/mL).


Humulin R U-500 is a prescription insulin used in adults and children who need more than 200 units of insulin a day to control high blood sugar for their diabetes mellitus. It is more concentrated than standard insulin. It has 5 times as much insulin in each mL as standard insulin.


It is not known if Humulin R U-500 is safe and effective when used with other insulins, when used in an insulin pump, or in children. There were no studies done in children, so your doctor will give you special instructions for use in children.

Warnings

Humulin R U-500 may cause serious side effects, including:

  • Severe low blood sugar, which can lead to seizures, unconsciousness, and death.
  • Severe allergic reactions. Get medical help right away if you develop a rash over your whole body, have trouble breathing, have a fast heartbeat, or are sweating.
  • Swelling of your hands and feet. Tell your doctor if you are short of breath, have swelling in your ankles, or have gained weight suddenly.
  • Heart failure when taking a medication from a class of drugs called thiazolidinediones (TZDs) with Humulin R U-500. This may occur in some people even if they have not had heart problems before.
  • Low potassium in your blood (hypokalemia). This can lead to severe breathing problems, irregular heartbeat, and death.

Do not share your Humulin R U-500 KwikPen® or U-500 syringe with anyone. Even if you have changed the needle, you or the other person can get a serious infection.


When using the Humulin R U-500 KwikPen: The Humulin R U-500 KwikPen is made to dial and deliver the correct dose of Humulin R U-500 insulin. Do not remove Humulin R U-500 from the KwikPen to inject with any syringe. This could cause severe overdose and may lead to death.


When using the Humulin R U-500 vial: There is a special syringe to measure Humulin R U-500 called the "U-500 insulin syringe." Only use the U-500 insulin syringe to inject Humulin R U-500. If you do not use the right syringe, you may take the wrong dose of Humulin R U-500. This could cause severe overdose and may lead to death.


Do NOT perform dose conversion when using the Humulin R U-500 KwikPen or U-500 insulin syringe.


Do not use Humulin R U-500 in an insulin pump or inject it into your vein or muscle.


Do not take this medicine if you have low blood sugar.


Do not change the insulin you use without talking to your doctor. Changing insulin may lead to low or high blood sugar.


Do not drive or use heavy machinery until you know how Humulin R U-500 affects you. Do not drink alcohol while using Humulin R U-500.

Common side effects

The most common side effects of Humulin R U-500 include:

  • Low blood sugar (hypoglycemia). Talk to your doctor about low blood sugar symptoms and treatment. Symptoms may be different for each person.
  • Allergic reactions, such as redness and swelling at the site where you inject.
  • Skin thickening or pits at the injection site (lipodystrophy).
  • Itching and rash.

These are not all the possible side effects of Humulin R U-500.

Tell your doctor if you have any side effects. You can report side effects at 1-800-FDA-1088 or www.fda.gov/medwatch.

Before using

Tell your doctor if you are pregnant or plan to become pregnant. Also tell your doctor about:

  • Any allergies you have. Your doctor can check if the medicine has ingredients that may cause a reaction.
  • Any medical conditions, including problems with your liver, kidney, or heart.
  • All the medicines you take, especially a class of drugs called thiazolidinediones, or TZDs. Be sure to include the over-the-counter medicines, vitamins, and herbal supplements you take.
How to take
  • Read the instructions that come with your Humulin R U-500 carefully. Take it exactly the way your doctor tells you.
  • Know how much Humulin R U-500 you are supposed to take. Do not change your dose unless your doctor tells you to.
  • Check the label of your insulin each time you use it. This will help you make sure you are using the right one.
  • Test your blood sugar before you take Humulin R U-500. Do not take it if your blood sugar is too low.
  • Do not mix Humulin R U-500 with any other insulin.
  • Always use a new needle when injecting Humulin R U-500. This will help you avoid infection.
  • Inject Humulin R U-500 under your skin. Change (rotate) where you inject your insulin with each dose. Do not inject your insulin into the exact same spot. Avoid injecting your insulin into areas where the skin has pits or lumps, or is thickened, tender, bruised, scaly, hard, scarred, or damaged. This will help reduce your chance of getting pits, lumps, or thickened skin where you inject your insulin.
Learn more

For more information, call 1-800-545-5979 or go to humulin.com.


This summary provides basic information about Humulin R U-500 but does not include all information known about this medicine. Read the information that comes with your prescription each time your prescription is filled. This information does not take the place of talking with your doctor. Be sure to talk to your doctor or other healthcare provider about Humulin R U-500 and how to take it. Your doctor is the best person to help you decide if Humulin R U-500 is right for you.


Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.


HM CON BS 15NOV2019