Choose Humulin R U-500 Insulin for treatment of patients with diabetes with a high daily insulin requirement
His daily insulin dose is above 200 units, but he continues to face challenges
Rising insulin needs
Needs >200 units of insulin per day (e.g., 100 units of basal/day and 35 units of U-100 insulin at each meal)
Rising A1C levels
Has an A1C above target and hasn’t improved despite increases in insulin
Is discouraged that 5 or more injections a day are not helping enough
Indication for Humulin® R U-500
• Humulin R U-500 is a concentrated human insulin indicated to improve glycemic control in adults and children with diabetes mellitus requiring more than 200 units of insulin per day.
• Limitations of Use: The safety and efficacy of Humulin R U-500 used in combination with other insulins, or when delivered by continuous subcutaneous infusion, has not been determined.
Select Safety Information for Humulin R U-500
• Humulin R U-500 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Humulin R U-500 or any of its excipients.
• Dosing Errors: Extreme caution must be observed in measuring the dose of Humulin R U-500 because inadvertent overdose may result in serious adverse reaction or life-threatening hypoglycemia.
Humulin R U-500 is the only insulin studied in a randomized clinical trial of patients requiring >200 units/day1
The Humulin R U-500 Initiation Trial was a 24-week, open-label, randomized study conducted in the United States and Puerto Rico. This study compared 2 treatment regimens (TID versus BID) for U-500 insulin for replacement of high-dose U-100 insulin.