
Why Wait?: You could keep her on a basal-bolus regimen or you could try a different option1
Struggles to manage 5 or more injections/day*
- BMI of 34
- Uses 201 – 300 units of insulin/day
- Uncontrolled A1C
- Tried diet & exercise and other diabetes meds
* Hypothetical patient profile
Indication for Humulin® R U-500
- Humulin R U-500 is a concentrated human insulin indicated to improve glycemic control in adults and children with diabetes mellitus requiring more than 200 units of insulin per day.
- Limitations of Use: The safety and efficacy of Humulin R U-500 used in combination with other insulins, or when delivered by continuous subcutaneous infusion, has not been determined.
Select Important Safety Information
Contraindications
Humulin® R U-500 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Humulin R U-500 or any of its excipients.
Humulin R U-500 is the only insulin studied in a randomized clinical trial of patients requiring >200 units/day1
Trial Objective
The Humulin R U-500 Initiation Trial was a 24-week, open-label, randomized study conducted in the United States and Puerto Rico. This study compared 2 treatment regimens (TID versus BID) for U-500 insulin for replacement of high-dose U-100 insulin.