Humulin R U-500 is a concentrated insulin
U-500 is 5 times more concentrated than standard U-100 insulin. When insulin is concentrated, it takes less liquid per dose than standard U-100 insulin to help reduce your blood sugar levels.
With U-500, you can inject up to 80% less liquid and still get the dose you need. Reducing the amount of liquid may also reduce the number of times you have to inject in a day.* And because U-500 can be prescribed by itself, you may be able to reduce the number of insulins you take.