Humulin R U-500 could mean fewer daily injections.*1
In the Initiation Trial, U-500 lowered A1C using 2 or 3 injections a day for patients uncontrolled on high-dose U-100 insulin.1 Below is the guidance developed from the trial.
A clinical framework for transitioning patients from U-100 insulin to U-5001
Algorithms are based on the U-500 Initiation Trial.
Click here for full study details
STEP 1: Determine Starting Dose1
How starting doses were determined in
the U-500 Initiation Trial:
- If A1C was >8% at Week -4 and mean self-monitored plasma glucose (SMPG) ≥183 mg/dL in the 7 days before Week 0, then the starting total daily dose (TDD) of U-500 was 100% of the final U-100 TDD
- If A1C was ≤8% at Week -4 or mean SMPG <183 mg/dL in the 7 days before Week 0, then the starting TDD of U-500 was 80% of the final U-100 TDD (20% reduction)
STEP 2: Determine Dose Proportions*1
Study participants were randomized to either TID or BID regimens1:
- TID: 40% of TDD before breakfast, 30% before lunch, and 30% before dinner
- BID: 60% of TDD before breakfast and 40% before dinner