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For Healthcare Professionals

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Frequently
Asked Questions

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Coverage and Payment

Does Medicare cover my U-500 insulin prescription?

Humulin R U-500 is covered by many Medicare Part D plans. For information on whether your specific plan covers U-500, call your insurance carrier.

Does Medicaid cover my U-500 insulin prescription?

Humulin R U-500 is covered by many state Medicaid plans. For information on whether your specific plan covers U-500, call your insurance carrier.

Does insurance cover my U-500 insulin prescription?

Humulin R U-500 is covered by most commercial insurance plans (for example, insurance you may receive from work). In addition, we offer a savings card that can help eligible, commercially insured patients with their prescription co-pay. Learn more about our savings card program here.

Where can I get a Humulin R U-500 Savings Card?*

If you have insurance through your employer or independent insurance that is not a government-sponsored plan (for example, Medicaid or Medicare), ask your doctor for a U-500 Savings Card or download a card here.

*Restrictions apply. Click here to see Eligibility Requirements.

Why do I have to activate my Humulin R U-500 Savings Card?*

Activating your savings card ensures that your card is ready for use and that you meet the eligibility requirements. It also offers the opportunity for you to sign up to receive continued information about this and other products.

*Restrictions apply. Click here to see Eligibility Requirements.

What should I do if my pharmacist doesn’t give me the right amount of U-500?

Ask your pharmacist to contact your doctor to confirm the number of units of insulin you should receive. Or ask your pharmacist to call 1-800-LillyRx (1-800-545-5979) to clarify how to fill the prescription.

Still have questions about the savings card? Call 1-866-923-1953.

About Humulin® R U-500 Insulin

How long can I use Humulin R U-500?

There is an expiration date on each label of Humulin R U-500. Do not use after the expiration date.

Once opened, Humulin R U-500 KwikPen should be used within 28 days and must be stored at room temperature (up to 86°F [30°C]).Throw away the pen you are using after 28 days, even if there is insulin left. A vial of Humulin R U-500 can be used for 40 days after opening and can be stored either in the refrigerator or at room temperature. After 40 days, any remaining insulin in the vial should be discarded.

Do I need to convert my dose?

If you are getting U-500 in the KwikPen, there is no conversion needed. Dial the prescribed dose, which will be in 5-unit increments. Then inject the dose as instructed by your doctor.

Similarly, if you are using the U-500 insulin syringe, there is no dose conversion needed. Each line of the syringe measures 5 units of insulin. Your doctor should tell you how much Humulin R U-500 insulin to take in units and when to take it. Your doctor should show you how to draw up your dose using the U-500 syringe.

Always inject Humulin R U-500 insulin with a U-500 syringe. Other syringes will not measure your dose correctly. If you use the wrong syringe, you can give yourself a severe overdose. This can cause very low blood sugar, which may put your life in danger. For example, using a U-100 syringe can give you a 5 times overdose.

If I am hospitalized, what should I tell the hospital staff about U-500?

If hospitalized or you go to the emergency room, make sure to tell the hospital staff the dose of Humulin R U-500 in units of insulin that your doctor has prescribed.

Could I have fewer injections on Humulin R U-500?

Yes, you may have fewer injections compared with standard U-100 insulin. Your doctor may have eliminated one or more of your insulins when transitioning you onto U-500, and that may also reduce the number of injections you take on a daily basis. Most people will take U-500 2-3 times a day.

What do I do with my remaining U-100 insulin?

Consult your doctor for important considerations when transitioning medicines.

Where do I inject U-500 insulin?

Inject your insulin as your doctor has shown you.

  • Change (rotate) your injection site for each injection
  • Do not try to change your dose while injecting
  • Choose an injection site
    • Humulin is injected under the skin (subcutaneously) of your stomach area, buttocks, upper legs, or upper arms
  • Wipe your skin with an alcohol swab, and let your skin dry before you inject your dose

View the demonstration video for more information.

What are the potential side effects of U-500?

Humulin R U-500 can cause low blood sugar that is severe and that can last a long time. Symptoms of low blood sugar may happen suddenly and may include sweating, dizziness, drowsiness, headache, or other symptoms. Severe low blood sugar can cause you to become confused, pass out (become unconscious), have seizures or coma, and could cause death. Talk with your doctor about how to tell if you have low blood sugar and what to do if this happens while taking Humulin R U-500. Follow your doctor’s instructions for treating your low blood sugar. Tell your doctor if low blood sugar is a problem for you. Your doctor may need to change the amount of Humulin R U-500 that you take, or change your meal plans or your exercise program to help you avoid low blood sugar.

What should I do if I am experiencing any side effects?

If you are experiencing any side effects, please contact your doctor. Get emergency medical help if you have severe low blood sugar; trouble breathing; shortness of breath; fast heartbeat; swelling of your face, tongue, or throat; sweating; extreme drowsiness; dizziness; or confusion. You may also report side effects to the Food and Drug Administration at 1-800-FDA-1088.

Why are there differences in the U-500 packaging?

You may notice some differences in the packaging of your Humulin R U-500 insulin vial. The packaging may be white with brown stripes, or it may be aqua and white. Both packages contain U-500 insulin. Just be sure it’s labeled “Humulin R” and “U-500.” Check that the expiration date on the medication has not passed.

Still have questions about Humulin® R U-500? To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979).

The Humulin® R U-500 KwikPen®

How much insulin will I get per box?

Each Humulin R U-500 KwikPen holds 1500 units of insulin, and each box of U-500 contains 2 pens. You’ll get a total of 3000 units per box (compared to most U-100 disposable pens that hold 300 units of insulin and are sold in boxes of five, for a total of 1500 units per box.) Based on the dose your doctor prescribed, you may get multiple boxes per prescription fill each month.

Why am I only getting 2 pens per box?

Because Humulin R U-500 KwikPen contains 1500 units per pen, you are getting approximately double the number of units of insulin per box compared to most standard U-100 disposable insulin pens that come in a box of 5.

How is Humulin R U-500 KwikPen different from my current U-100 pen?

With the U-500 KwikPen, you may notice some differences:

  • Aqua color
  • It holds 1500 units per pen (standard U-100 pens hold 300 units)
  • It doses as much as 300 units at one time and dials in 5-unit increments (standard U-100 pens dial and dose in single-unit increments)
  • It comes 2 pens per pack

Depending on the insulin you were on before, Humulin R U-500 may have other important differences. Talk to your doctor to learn more or call 1-800-LillyRx (1-800-545-5979).

Because the U-500 pen holds 5 times the insulin, is it larger than other standard U-100 insulin pens?

No, it holds 3 mL of insulin just like other standard U-100 insulin pens, and it is similar in size to other KwikPens.

How were you able to fit 1500 units of insulin in one pen?

Because Humulin R U-500 is 5 times more concentrated than standard U-100 insulin, it requires 80% less liquid to deliver the same amount of medicine. Each Humulin R U-500 KwikPen contains 1500 units of insulin, instead of the 300 units found in standard U-100 insulin disposable pens. Most patients will require 2-3 daily injections.

Please see Instructions for Use included with the pen

Will there be insulin left in my pen when it’s time to discard it?

Each Humulin R U-500 KwikPen contains 1500 units of insulin, instead of the 300 units of insulin found in many standard U-100 disposable pens. If you use more than 200 units of insulin a day, you should be able to use an entire Humulin R U-500 KwikPen within 28 days. Remember: Never withdraw Humulin R U-500 from the pen using a syringe. It could result in a severe overdose. Also, remember to discard the pen after 28 days even if there is insulin still remaining.

Do I prime my pen before using?

Yes, you need to prime it before every injection. View the demonstration video or see the Instructions for Use for more information.

Priming your pen means removing the air from the needle and cartridge that may collect during normal use and ensures that the pen is working correctly. If you do not prime before each injection, you may get too much or too little insulin.

View the demonstration video for more information.

What should I do if my KwikPen dose knob is hard to push?

If it is hard to push the dose knob:

  • Pushing the dose knob more slowly will make it easier to inject
  • Your needle may be blocked. Put on a new needle and prime the pen
  • You may have dust, food, or liquid inside the pen. Throw the pen away and get a new pen

If you have any questions or problems with your Humulin R U-500 KwikPen, contact Lilly at 1-800-LillyRx (1-800-545-5979) or call your healthcare provider for help.

Remember: Never withdraw Humulin R U-500 from the pen using a syringe. It could result in a severe overdose. Also, remember to discard the pen after 28 days even if there is insulin still remaining.

View the demonstration video for more information.

Still have questions about Humulin® R U-500? To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979).

The BD™ U-500 Insulin Syringe and the Humulin R U-500 Insulin Vial

Why do I need to use a U‑500 syringe?

Humulin R U‑500 insulin and a BD U-500 Insulin Syringe work together to help you inject the correct dose. Using any other syringe may result in dosing mistakes. This may put your life in danger.

What should I do if I run out of U‑500 syringes?

If you run out of U‑500 syringes, do not use any other syringe to inject Humulin R U‑500 insulin. Call your healthcare provider or pharmacist for help. You may also call Lilly at 1‑800‑Lilly‑Rx (1‑800‑545‑5979).

Do I have to convert my Humulin R U‑500 insulin dose when I use the U‑500 syringe?

No, you do not have to convert your dose. Your healthcare provider should tell you how much Humulin R U‑500 insulin to take in units and when to take it. Your healthcare provider should show you how to draw up your dose using the U‑500 syringe.

What should I do if my pharmacist doesn't give me the right amount of U-500 syringes?

Ask your pharmacist to confirm that you received the number of syringes your heathcare provider wrote on your prescription. If you are short of syringes, ask your pharmacist to call the healthcare provider.

If you run out of U-500 syringes, do not use any other syringe to inject Humulin R U-500 insulin.

Still have questions about Humulin® R U-500? To chat, click the “Ask Lilly” box in the upper right corner. Or call 1-800-LillyRx (1-800-545-5979).

Resources and Support

Who can I contact if I have additional questions about U-500?

If you have additional questions about taking your U-500, please contact your healthcare provider, pharmacist, or The Lilly Answers Center at 1-800-LillyRx (1-800-545-5979).

What if I can't afford my U-500 prescription?

If you need help paying for your U-500 prescription, the Lilly Cares Foundation may be able to help qualified patients. For additional information, contact LillyCares.com or call 1-800-545-6962.

Indication for Humulin R U-500

  • Humulin R U‑500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day.
  • Humulin R U‑500 contains 5 times as much insulin in the same volume (500 units/mL) as standard insulin (100 units/mL).
  • It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins, when used in an insulin pump, or in children.

Indication for Humulin® R U-500

  • Humulin R U-500 is a concentrated human insulin indicated to improve glycemic control in adults and children with diabetes mellitus requiring more than 200 units of insulin per day.
  • Limitation of Use: The safety and efficacy of Humulin R U-500 used in combination with other insulins has not been determined. The safety and efficacy of Humulin R U-500 delivered by continuous subcutaneous infusion has not been determined.
VIEW ALL > VIEW ALL >

Important Safety Information for Humulin R U-500

What is the most important information I should know about Humulin R U-500?

  • Humulin R U-500 is highly concentrated and contains 5 times as much insulin in 1 mL as standard U-100 (100 units/mL) insulin.
  • Do not share your Humulin R U-500 KwikPen or U-500 insulin syringes with other people, even if the needle has been changed. You may give other people a serious infection or get a serious infection from them.

Who should not take Humulin R U-500?

  • Do not take Humulin R U-500 if your blood sugar is too low (hypoglycemia) or you are allergic to any of the ingredients in Humulin R U-500.

What should I tell my healthcare provider before taking Humulin R U-500?

  • Tell your healthcare provider:
    • If you have liver, kidney, or heart problems or any other medical conditions.
    • If you are pregnant, plan to become pregnant, or are breast-feeding.
    • About all the medicines you take, including prescription (especially ones commonly called TZDs [thiazolidinediones]) and over the counter medicines, vitamins, and herbal supplements.
  • Before you start using Humulin R U-500, talk to your healthcare provider about low blood sugar and how to manage it.

How should I use Humulin R U-500?

  • Read the detailed Instructions for Use that come with your Humulin R U-500.
  • Take Humulin R U-500 exactly as your healthcare provider tells you to. Your healthcare provider should show you how much Humulin R U-500 to use and when to use it.
  • Know the dose of Humulin R U-500 you use. Do not change your dose unless your healthcare provider tells you to.
  • Check your insulin label each time you give your injection to make sure you are using the correct insulin.
  • Humulin R U-500 KwikPen: The U-500 KwikPen is specially made to dial and deliver doses of Humulin R U-500 insulin. Do not use any syringe to remove Humulin R U-500 insulin from your U-500 KwikPen. The markings on certain syringes will not measure your dose correctly. A severe overdose can happen, causing low blood sugar, which may put your life in danger.
  • Humulin R U-500 vial: There is a special U-500 insulin syringe to measure Humulin R U-500. Use only a U-500 insulin syringe to draw up and inject your Humulin R U-500. If you do not use the right syringe type, you may take the wrong dose of Humulin R U-500. This can cause you to have too low blood sugar (hypoglycemia) or too high blood sugar (hyperglycemia). Your healthcare provider should show you how to draw up Humulin R U-500.
  • Use Humulin R U-500 30 minutes before eating a meal.
  • Inject Humulin R U-500 under your skin (subcutaneously). Do not use Humulin R U-500 in an insulin pump or inject Humulin R U-500 into your vein (intravenously) or your muscle (intramuscularly).
  • Do not mix Humulin R U-500 with any other type of insulin or liquid medicine.
  • Change your injection site with each dose.
  • Check your blood sugar levels. Ask your healthcare provider what your blood sugar level should be and when you should check your blood sugar.
  • Your dose of Humulin R U-500 may need to change because of changes in your level of exercise, weight, or diet, or because of increased stress, illness, or other medicines you take.
  • Keep Humulin R U-500 and all medicines out of the reach of children.

What should I avoid while taking Humulin R U-500?

  • Do not drive or operate heavy machinery until you know how Humulin R U-500 affects you. Do not drink alcohol or use over-the-counter medicines that contain alcohol.

What are the possible side effects of Humulin R U-500?

  • Humulin R U-500 can cause serious side effects that can lead to death, including:
    • Low blood sugar. Signs of low blood sugar may include dizziness or lightheadedness, sweating, confusion, headache, blurred vision, slurred speech, shakiness, fast heartbeat, anxiety, irritability or mood changes, or hunger. Your healthcare provider may prescribe a glucagon emergency kit so that others can give you an injection if your blood sugar becomes too low (hypoglycemic) and you are unable to take sugar by mouth.
    • Severe allergic reaction. Get medical help right away if you have a rash over your whole body, have trouble breathing, a fast heartbeat, or sweating. These are signs of a severe allergic reaction.
    • Low potassium in your blood.
    • Heart failure. Taking certain diabetes pills called thiazolidinediones or “TZDs” with Humulin R U-500 may cause heart failure in some people. This can happen even if you have never had heart failure or heart problems before. If you already have heart failure, it may get worse while you take TZDs with Humulin R U-500. Your healthcare provider should monitor you closely while you are taking TZDs with Humulin R U-500. Tell your healthcare provider if you have any new or worse symptoms of heart failure, including shortness of breath, swelling of your ankles or feet, or sudden weight gain.
      Treatment with TZDs and Humulin R U-500 may need to be adjusted or stopped by your healthcare provider if you have new or worse heart failure.
  • Get emergency medical help if you have:
    • severe low blood sugar needing hospitalization or emergency room care. Be sure to tell the hospital staff the units of Humulin R U-500 that your healthcare provider has prescribed for you.
    • trouble breathing, shortness of breath, fast heartbeat, swelling of your face, tongue, or throat, sweating, extreme drowsiness, dizziness, confusion.
  • The most common side effects of Humulin R U-500 include low blood sugar, allergic reactions including reactions at your injection site, skin thickening or pits at the injection site, itching, and rash.
  • These are not all of the possible side effects of Humulin R U-500. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I store Humulin R U-500?

  • Keep away from heat and out of direct light. Do not freeze. Do not use Humulin R U-500 after the expiration date stamped on the label. Do not shake the vial.
  • Humulin R U-500 Vials: Store unopened vials of Humulin R U-500 in a refrigerator. Store opened (in-use) vials of Humulin R U-500 in the refrigerator or at room temperature for up to 40 days. Throw away any opened vial after 40 days of use, even if there is insulin left in the vial.
  • Humulin R U-500 KwikPen: Store unopened Humulin R U-500 KwikPens in a refrigerator. Store opened (in-use) Humulin R U-500 KwikPens at room temperature for up to 28 days. Do not refrigerate opened KwikPens. Throw away any opened KwikPen after 28 days of use, even if there is insulin left in the pen.

General Information about the safe and effective use of Humulin R U-500

  • Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use Humulin R U-500 for a condition for which it was not prescribed. Do not give Humulin R U-500 to other people, even if they have the same symptoms you have. It may harm them.
  • The Patient Information leaflet summarizes the most important information about Humulin R U-500. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Humulin R U-500 that is written for healthcare professionals. For more information go to www.humulin.com or call 1-800-545-5979.

Humulin R U-500 is available by prescription only.

For additional information, talk to your healthcare provider and please click to access Full Prescribing Information, Patient Information, and Instructions for Use for vial and pen.

HI U500 CON ISI 27SEP2016

Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates.

BD™ is a trademark of Becton, Dickinson and Company.

Important Safety Information for Humulin R U-500

Contraindications

  • Humulin R U-500 is contraindicated during episodes of hypoglycemia and in patients hypersensitive to Humulin R U-500 or any of its excipients.

Warnings and Precautions

  • Dosing Errors: Extreme caution must be observed in measuring the dose of Humulin R U-500 because inadvertent overdose may result in serious adverse reaction or life-threatening hypoglycemia.
  • Hyperglycemia, Hypoglycemia or Death Due to Dosing Errors in the Vial Presentation: Medication errors associated with the Humulin R U-500 vial resulting in patients experiencing hyperglycemia, hypoglycemia or death have been reported.

Dispensing

  • Instruct patients to always inspect insulin vials to confirm that the correct insulin is dispensed including the correct brand and concentration.
  • For the Humulin R U-500 vial, particular attention should be paid to the 20-mL vial size, prominent “U-500” and warning statements on the vial label, and distinctive coloring on the vial and carton.

Prescribing

  • Dosing errors have occurred when Humulin R U-500 was administered with syringes other than a U-500 insulin syringe. Patients should be prescribed U-500 syringes for use with Humulin R U-500 vials. The dose of Humulin R U-500 should always be expressed in units of insulin.

Administration

  • Instruct patients to always check the insulin label before each injection.
  • Use only a U-500 insulin syringe with Humulin R U-500 to avoid administration errors. Do not use any other type of syringe to administer Humulin R U-500. Adhere to administration instructions.
  • Instruct the patient to inform hospital or emergency department staff of the dose of Humulin R U-500 prescribed.
  • If using the Humulin R U-500 KwikPen, patients should be counseled to dial and dose the prescribed number of units of insulin (NO dose conversion is required).
  • DO NOT transfer Humulin R U-500 from the Humulin R U-500 KwikPen into any syringe for administration. Overdose and severe hypoglycemia can occur.
  • Never Share a KwikPen or U-500 Syringe Between Patients, even if the needle is changed. Sharing poses a risk for transmission of blood-borne pathogens.
  • Hyperglycemia or Hypoglycemia with Changes in Insulin Regimen: Changes in insulin, manufacturer, type, or method of administration should be made cautiously and only under medical supervision and the frequency of blood glucose monitoring should be increased.
  • Hypoglycemia: Hypoglycemia is the most common adverse reaction associated with insulin, including Humulin R U-500. Severe hypoglycemia can cause seizures, may be life-threatening, or cause death. Severe hypoglycemia may develop as long as 18 to 24 hours after an injection of Humulin R U-500. Hypoglycemia can impair concentration ability and reaction time; this may place an individual and others at risk in situations where these abilities are important, such as driving or operating other machinery.
  • Hypoglycemia can happen suddenly and symptoms may differ in each individual and change over time in the same individual.
  • Early warning symptoms of hypoglycemia may be less pronounced in patients with longstanding diabetes, in patients with diabetic nerve disease, in patients using medications that block the sympathetic nervous system, or in patients who experience recurrent hypoglycemia.
  • The timing of hypoglycemia usually reflects the time-action profile of the administered insulin formulation. As with all insulin preparations, the glucose lowering effect time course of Humulin R U-500 may vary in different individuals or at different times in the same individual and depends on many conditions.
  • Patients and caregivers must be educated to recognize and manage hypoglycemia. Self-monitoring of blood glucose plays an essential role in the prevention and management of hypoglycemia. In patients at higher risk for hypoglycemia and patients who have reduced symptomatic awareness of hypoglycemia, increased frequency of blood glucose monitoring is recommended.
  • Hypersensitivity and Allergic Reactions: Severe, life-threatening, generalized allergy, including anaphylaxis, can occur with insulin products, including Humulin R U-500. If hypersensitivity reactions occur, discontinue Humulin R U-500; treat per standard of care and monitor until symptoms and signs resolve.
  • Hypokalemia: Insulin use can lead to hypokalemia that left untreated may cause respiratory paralysis, ventricular arrhythmia, and death. Use caution in patients who may be at risk for hypokalemia (e.g., patients using potassium-lowering medications, patients taking medications sensitive to serum potassium concentrations).
  • Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Thiazolidinediones (TZDs), which are PPAR-gamma agonists, can cause dose-related fluid retention, particularly when used in combination with insulin. Fluid retention may lead to or exacerbate heart failure. Observe patients for signs and symptoms of heart failure. If heart failure develops, it should be managed according to current standards of care, and discontinuation or dose reduction of the PPAR-gamma agonist must be considered.

Adverse Reactions

  • Adverse reactions include hypoglycemia, allergic reactions, lipodystrophy, injection site reactions, weight gain, peripheral edema, and immunogenicity.

Drug Interactions

  • Some medications may alter glucose metabolism and may necessitate insulin dose adjustment. Signs of hypoglycemia may be reduced or absent in patients taking antiadrenergic drugs. Particularly close monitoring may be required.

Use in Specific Populations

  • Pregnancy Category B: While there are no adequate and well-controlled studies in pregnant women, evidence from published literature suggests that good glycemic control in patients with diabetes during pregnancy provides significant maternal and fetal benefits.
  • Pediatric Use: There are no well-controlled studies of use of Humulin R U-500 in children. Standard precautions as applied to use of Humulin R U-500 in adults are appropriate for use in children.
  • Geriatric Use: There are no well-controlled studies of use of Humulin R U-500 in geriatric patients. In elderly patients with diabetes, the initial dosing, dose increments, and maintenance dosage should be conservative to avoid hypoglycemia.
  • Renal or Hepatic Impairment: Frequent glucose monitoring and insulin dose reduction may be required in patients with renal or hepatic impairment.

Dosage and Administration

  • Prescribe Humulin R U-500 ONLY to patients who require more than 200 units of insulin per day.
  • Humulin R U-500 is available as a KwikPen or a multiple dose vial. Patients using the vial must be prescribed the U-500 insulin syringe to avoid medication errors.
  • DO NOT perform dose conversion when using the Humulin R U-500 KwikPen. The dose window of the KwikPen shows the number of units of Humulin R U-500 to be injected and NO dose conversion is required.
  • DO NOT perform dose conversion when using a U-500 insulin syringe. The markings on the syringe show the number of units of Humulin R U-500 to be injected. Each marking represents 5 units of insulin.
  • Instruct patients using the vial to use only a U-500 insulin syringe and on how to correctly draw the prescribed dose into the syringe. Confirm that the patient has understood these instructions and can correctly draw the prescribed dose with their syringe.
  • Advise the patient to read the Patient Information and Instructions for Use.
  • Instruct patients to always check the insulin label before administration to confirm the correct insulin product is being used.
  • Inspect Humulin R U-500 visually and only use if the solution appears clear and colorless.
  • Administer Humulin R U-500 subcutaneously two or three times daily approximately 30 minutes before a meal. Rotate injection sites to reduce the risk of lipodystrophy.
  • Individualize the dose of Humulin R U-500 based on metabolic needs, blood glucose monitoring results, and glycemic control goal.
  • Do NOT administer Humulin R U-500 intravenously or intramuscularly.
  • Do NOT mix Humulin R U-500 with other insulins.

Storage

  • Protect from heat and light. Do not freeze. Do not use Humulin R U-500 after the expiration date stamped on the label.
  • Humulin R U-500 Vials: Unopened vials of Humulin R U-500 should be kept in a refrigerator. Opened (in-use) vials of Humulin R U-500 should be kept in the refrigerator or at room temperature and used within 40 days of opening. Throw away any opened vial after 40 days of use, even if there is insulin left in the vial.
  • Humulin R U-500 KwikPen: Unopened Humulin R U-500 KwikPens should be kept in a refrigerator. Opened (in-use) Humulin R U-500 KwikPens should be kept at room temperature and used within 28 days of opening. Do not refrigerate opened KwikPens. Throw away any opened KwikPen after 28 days of use, even if there is insulin left in the pen.

Please click to access Patient Information, Full Prescribing Information, and Instructions for Use for the pen and vial.

HM U500 HCP ISI 27SEP2016

Humulin® and KwikPen® are registered trademarks owned or licensed by Eli Lilly and Company, its subsidiaries, or affiliates. Humulin® R U-500 is available by prescription only.

BD™ is a trademark of Becton, Dickinson and Company.

VIEW ALL > VIEW ALL >
Tap to view Important Safety Information

Indication for Humulin R U-500

  • Humulin R U‑500 is an insulin that is used to control high blood sugar in adults and children with diabetes mellitus who need more than 200 units of insulin in a day.
  • Humulin R U‑500 contains 5 times as much insulin in the same volume (500 units/mL) as standard insulin (100 units/mL).
  • It is not known if Humulin R U-500 is safe and effective when used in combination with other insulins, when used in an insulin pump, or in children.
Tap to view Important Safety Information

Indication for Humulin® R U-500

  • Humulin R U-500 is a concentrated human insulin indicated to improve glycemic control in adults and children with diabetes mellitus requiring more than 200 units of insulin per day.
  • Limitation of Use: The safety and efficacy of Humulin R U-500 used in combination with other insulins has not been determined. The safety and efficacy of Humulin R U-500 delivered by continuous subcutaneous infusion has not been determined.

PP-HM-US-0854  08/2017  ©Lilly USA, LLC 2017. All rights reserved. This site is intended for US residents ages 18 and over. Models used for illustrative purposes only. Not actual patients or healthcare providers.

PP-HM-US-0854  08/2017  ©Lilly USA, LLC 2017. All rights reserved. This site is intended for US healthcare professionals only. Models used for illustrative purposes only. Not actual patients.

For Healthcare Professionals

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