Discover Humulin U-100 Formulations for Managing Type 1 and Type 2 Diabetes

For the treatment of high blood sugar (glucose) levels, three types of Humulin^® U-100 formulations can help manage diabetes and are available without a prescription. Each type varies in how fast it starts working and how long the effects last. Keep in mind that insulin should only be used under a doctor's advice and direction.

Humulin is similar to the insulin the body makes naturally. Introduced by Eli Lilly and Company in 1982, Humulin U-100 formulations
are affordable insulin choices that celebrate 30 years of helping children and adults manage type 1 and type 2 diabetes.

	Humulin® R U-100 is a short-acting insulin. There are two Humulin R formulations: Humulin R U-100 and a higher insulin concentration formulation. It's important to ensure you have the correct formulation. Humulin R U-100 is for injection under the skin. It should not be injected into the muscle. Doses of insulin are measured in units. U-100 insulins, including Humulin R, contain 100 units/mL. With Humulin R, it is important to use a syringe that is marked for U-100 insulin preparations. Do not use Humulin R U-100: if it appears cloudy, thickened, or slightly colored, or if solid particles are visible If you notice your insulin requirements changing, talk to your doctor. Be sure to read the Patient Information that comes with your Humulin R U-100 insulin.
	Humulin® N is an intermediate-acting insulin that is slower to act and lasts longer than regular human insulin. Humulin N is also available in a prefilled pen. Humulin N is injected under the skin. It should not be injected into the muscle or veins. Doses of insulin are measured in units. U-100 insulins, including Humulin N, contain 100 units/mL. With Humulin N, it is important to use a syringe that is marked for U-100 insulin preparations. Do not use Humulin N: if the insulin substance (the white material) remains at the bottom of the bottle after mixing, or if there are clumps in the insulin after mixing, or if solid white particles stick to the bottom or walls of the bottle or cartridge, giving a frosted appearance If you notice your insulin requirements changing, talk to your doctor. Be sure to read the Information for the Patient that comes with your Humulin N insulin or Humulin N prefilled pen. Also, if you're using the prefilled pen, the user manual can be found in your pen box or by clicking here.
	Humulin® 70/30 is an intermediate-acting insulin, combining the short action of regular human insulin and the intermediate action of Humulin N. Humulin 70/30 is also available in a prefilled pen. Humulin 70/30 is injected under the skin. It should not be injected into the muscle. Doses of insulin are measured in units. U-100 insulins, including Humulin 70/30, contain 100 units/mL. With Humulin 70/30, it is important to use a syringe that is marked for U-100 insulin preparations. Do not use Humulin 70/30: if the insulin substance (the white material) remains at the bottom of the bottle after mixing, or if there are clumps in the insulin after mixing, or if solid white particles stick to the bottom or wall of the bottle or cartridge, giving a frosted appearance If you notice your insulin requirements changing, talk to your doctor. Be sure to read the Information for the Patient that comes with your Humulin 70/30 insulin or Humulin 70/30 prefilled pen. Also, if you're using the prefilled pen, the user manual can be found in your pen box or by clicking here.

Do not use any other insulin except on your doctor's advice and direction.

Important Considerations for Use for Humulin R, Humulin N, and Humulin 70/30:

• Low blood sugar (hypoglycemia) is the most common side effect of insulin, including Lilly Humulin insulins. Signs of severe hypoglycemia can include: disorientation, unconsciousness, seizures, or death.
• Any change of insulin should be made cautiously and only under medical supervision.
• Changes in strength, manufacturer, type (eg, regular, NPH, analog), species, or method of manufacture may result in the need for a change
  in dosage.
• Some patients taking Humulin may require a change in dosage from that used with other insulins. If an adjustment is needed, it may occur
  with the first dose or during the first several weeks or months.
• High blood sugar (hyperglycemia) may develop if the body has too little insulin. In people with type 1 or insulin-dependent diabetes, prolonged hyperglycemia can result in diabetic ketoacidosis (DKA). DKA is a life-threatening emergency.
• Always check the carton and bottle label for the name and letter designation of the insulin received from the pharmacy to make sure it's the correct insulin.
• Do not use any other insulin except on your doctor's advice and direction.
• Do not use Humulin after the expiration date stamped on the label or if it has been frozen.
• Do not share needles or syringes, because you may give or get an infection.
• Before using Lilly Humulin insulin, tell your healthcare providers about all of your medical conditions, including liver, kidney, or heart problems, if you are pregnant or breast-feeding, and about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
• Serious side effects can include heart failure when taking certain pills called thiazolidinediones or “TZDs” with
  Lilly Humulin insulin. Tell your healthcare provider if you have any new or worse symptoms of heart failure,
  such as shortness of breath, swelling of your ankles or feet, or sudden weight gain.

For more safety information, please click to access Humulin R U-100 Patient Information, Humulin R U-100
Information for the Physician, Humulin N Information for the Patient, and Humulin 70/30 Information
for the Patient.

Humulin^® is a registered trademark of Eli Lilly and Company.